Endocrine Abstracts

Introduction: The glycogen storage disease (GSD) is a rare disorder of carbohydrate metabolism resulting from the defective synthesis and utilization of glycogen. GSD-1a is a subtype of GSD caused by a deficiency in glucose-6-phosphatase activity, which leads to decreased conversion of glucose-6-phosphate to glucose. The dominant features at presentation are hypoglycemia and lactic acidemia. Long-term complications include blood glucose lability, lactic acidemia, short stature...

Objectives: To evaluate the prevalence in our work center of pathology of adrenal glands and to assess the efficacy of the radiology imaging in the detection of especific features and to exclude malignancy lessions.Material and Methods: We included patients who presented some adrenal lesion with histological study after surgerie between January 2010 and December 2015 in the hospitals of Albacete, Almansa and Villarrobledo. We use the Pathological Anatomy...

Introduction: The widespread use of highly-active antiretroviral therapy (HAART) has drastically improved the life expectancy of patients with human immunodeficiency virus (HIV) infection. However, many of these drugs show multiple interactions with other treatments; protease inhibitors (PI) are especially troublesome as they interact with the hepatic cytochrome P450. There have been previous reports of both Cushing’s syndrome and adrenal insufficiency in patients treated...

Purpose: The purpose is to draw attention to rare cases of Pituitary Macroadenoma co-secreting Growth Hormone and Thyroid Stimulating Hormone with Polynodular Goiter and their importance and approach in current practice.Background: Pituitary adenomas with no hormonal clinical picture are known as ‘silent’ tumors. They are rarely reported and lacking pathogenic explanations.Method: We describe a case of Pituitary Macroaden...

Introduction: Thyrotoxicosis may be associated with anemia (10–34% of thyrotoxic patients), leucopenia (15–30%) and thrombocytopenia (2–5%). We present the case of a 13-year-old girl with Graves’ disease associated with severe pancytopenia.Case presentation: The patient presented with menorrahgia and symptoms suggestive of an upper respiratory tract infection. On examination she was afebrile with a pulse rate of 100/min at rest. She h...

Introduction: Hyperglycaemia occurs frequently in catecholamine-secreting tumours due to insulin suppression or induced insulin resistance. These changes can be reversible postoperatory (postOp).Objective: Our study aims to establish the impact of surgery in patients with catecholamine-secreting tumours upon glucose metabolism disorders, as well as the predictive factors for postOp diabetes-free patients.Methods: We retrospectively...

Background: The Swedish Pituitary Register (SPR) is a national quality register founded in 1991 by the Swedish Pituitary Group and it provides important data in the continuous quality assessment and improvement work within the Swedish health care system.The Swedish Pituitary Register Nursing Group (SPRNG) was formed by nurses at the University Hospitals, working with the register, in 2011.Purpose: To increase the coverage rate and ...

Background: Increased fibrinogen levels have been reported in prepubertal children and adolescents with growth hormone deficiency (GHD), which were reduced after rhGH treatment. rhGH treatment has also been shown to exert a beneficial effect on the amount of aPAI-1 in children with GHD.Aim: Of the study was to evaluate whether prepubertal GH deficient (GHD) children showed any impairment in coagulation- and fibrinolysis-related parameters and the effect ...

Introduction: RET germline mutation in codon 634 of exon 11 is one of the most frequent mutations of classical multiple endocrine neoplasia type 2A (MEN2A). Virtually all patients with classical MEN2A develop medullary thyroid carcinoma (MTC), which is often the first manifestation of the disease and usually occurs early in life. Pheochromocytomas (PHEOs) tend to be diagnosed several years later or simultaneously with the MTC.Case report: The pa...

Introduction: Primary hyperparathyroidism is the most common cause of hypercalcemia in the outpatient setting, and a single parathyroid adenoma is usually the culprit. Clinical presentation is commonly dictated by hypercalcemia. Symptoms can range from mild non-specific malaise and gastrointestinal disturbances, through bone disease, kidney stones, cardiovascular and neuromuscular dysfunction to, ultimately, coma and death. However, the vast majority of patien...